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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: ACS Chem Biol. 2011 May 23;6(7):753–760. doi: 10.1021/cb2000378

Figure 1.

Figure 1

Complement-targeted inhibitory mechanism and peptide sequences of compstatin analogues. (a) The complement cascade is initiated through at least three different mechanisms, which all converge in the proteolytic activation of C3 to C3b; C3b participates in a self-amplified loop than enhances the effect of complement activation. Inhibition by compstatin at the level of C3/C3b effectively stops the activation of all initiation pathways, the amplification loop and all downstream effects of complement activation. C1-C5: complement components 1–5; FB: factor B; FD: factor D; MAC: membrane attack complex; MBL: mannose-binding lectin; MASP: MBL-associated serine protease; P: properdin. (b) The sequences of compstatin analogues 1–5 used in this study. The two cystathionine isomers are depicted as Ala-Hcy or Hcy-Ala, depending on the position of the sulfur atom. Hcy: homocysteine; Trp(Me): 1-methyltryptophan.