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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: ACS Chem Biol. 2011 May 23;6(7):753–760. doi: 10.1021/cb2000378

Figure 3.

Figure 3

Single-cycle kinetics analysis of the thioether compstatin analogues and corresponding disulfide bond controls. Sets of five increasing concentrations were consecutively injected over a C3b surface (3000 RU density) in a single cycle. In the case of peptides 1–3, two sets of concentrations are superimposed for a better description of the full binding range and to achieve a well-defined affinity profile. The processed signals were fitted to a 1:1 binding model (orange simulation curves) and kinetic rate constants ka and kd were extracted (Table 1). The compstatin analogue used is shown in the top left corner of each plot. Plots show representatives of at least six data sets.