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. Author manuscript; available in PMC: 2012 Jul 15.

Published in final edited form as: ACS Chem Biol. 2011 May 23;6(7):753–760. doi: 10.1021/cb2000378

Scheme 3 — Synthesis of cystathionine-containing compstatin analogues 2, 3 and 5.^a,b

^a Reagents and conditions: a) SPPS; b) Pd(PPh₃)₄, PhSiH₃, DMF; c) piperidine, DMF; d) PyBOP, HOAt, ⁱPr₂EtN, DMF; e) CF₃CO₂H, H₂O, ⁱPr₃SiH, HS(CH₂)₂SH. ^b An asterisk indicates standard Fmoc-orthogonal side chain protection: Gln(Trt), Asp(O^tBu), Trp(Boc), His(Trt), Arg(Pbf), Thr(^tBu).