Table 1.
Kinetic rate constants, binding affinities, inhibitory potential and relative inhibitory activities (rIC50) of compstatin analogues.
| Peptide | ka (105 M−1s−1)a | kd (10−2 s−1)a | KD (nM)a | IC50 (nM)b | rIC50 |
|---|---|---|---|---|---|
| 1 | 5.6 ± 1.4 | 8.1 ± 1.1 | 150 ± 19 | 1900 ± 1200 | 1 |
| 2 | 5.5 ± 0.7 | 46.8 ± 5.7 | 847 ± 59 | > 20000 | >10 |
| 3 | 4.6 ± 0.5 | 11 ± 1.9 | 236 ± 20 | 3100 ± 1800 | 1.6 |
|
| |||||
| 4 | 18.6 ± 4.1 | 0.4 ± 0.1 | 2.4 ± 0.6 | 130 ± 40 | 1 |
| 5 | 16.4 ± 3.8 | 1.5 ± 0.4 | 9 ± 1.8 | 270 ± 80 | 2.1 |
a
Results show average and standard deviations of at least six data sets.
b
Results show average and standard deviations of at least five data sets.