Table 3.
Schizophrenia candidate genes residing in CNVs in Dutch case-control study
| Gene | Position | # CNVs overlapping | # Cases (%) | # Controls (%) | |||
|---|---|---|---|---|---|---|---|
| Del | Dup | Del | Dup | Del | Dup | ||
| A2BP1 (15) | 16p13.2 | 4 | 3 | 3 (0.69) | - | 1 (0.28) | 3 (0.85) |
| ADAMTSL3 (18) | 15q25.2 | 0 | 0 | - | - | - | - |
| ADORA2A (47) | 22q11.23 | 0 | 0 | - | - | - | - |
| APBA2 (18;48;49) | 15q13.1 | 0 | 0 | - | - | - | - |
| ASTN2 (13) | 9q33.1 | 0 | 1 | - | 1 (0.23) | - | - |
| CABIN1 (47) | 22q11.23 | 0 | 0 | - | - | - | - |
| CHRNA7 (11;12) | 15q13.3 | 3 | 2 | 3 (0.69) | - | - | 2 (0.56) |
| CIT (15) | 12q24.23 | 0 | 0 | - | - | - | - |
| CNTNAP2 (50) | 7q35-q36.1 | 3 | 0 | 3 (0.69) | - | - | - |
| COMT (37;38) | 22q11.21 | 1 | 0 | 1 (0.23) | - | - | - |
| CTNND2 (13) | 5p15.2 | 0 | 1 | - | 1 (0.23) | - | - |
| CYFIP1 (11) | 15q11.2 | 7 | 10 | 4 (0.92) | 6 (1.39) | 3 (0.85) | 4 (1.13) |
| DISC1 (51) | 1q42.2 | 0 | 5 | - | 3 (0.69) | - | 2 (0.56) |
| DLGAP2 (48) | 8p23.3 | 0 | 0 | - | - | - | - |
| DOC2A (48) | 16p11.2 | 0 | 0 | - | - | - | - |
| EFCAB2 (18) | 1q44 | 0 | 1 | - | 1 (0.23) | - | - |
| ERBB4 (14) | 2q34 | 1 | 0 | 1 (0.23) | - | - | - |
| GJA8 (11) | 1q21.1 | 0 | 0 | - | - | - | - |
| GSTM1 (47) | 1p13.3 | 0 | 0 | - | - | - | - |
| GSTT2 (47) | 22q11.23 | 0 | 1 | - | - | - | 1 (0.28) |
| KIF26B (18) | 1q44 | 1 | 1 | 1 (0.23) | 1 (0.23) | - | - |
| MAPT (48) | 17q21.31 | 0 | 0 | - | - | - | - |
| MYT1L (13) | 2p25.3 | 0 | 2 | - | 2 (0.46) | - | - |
| NDE1 (52) | 16p13.1 | 0 | 6 | - | 3 (0.69) | - | 3 (0.85) |
| NDNL2 (48) | 15q13.1 | 0 | 0 | - | - | - | - |
| NOTCH4 (41;53) | 6p21.32 | 0 | 0 | - | - | - | - |
| NRGN (41) | 11q24.2 | 0 | 0 | - | - | - | - |
| NRXN1 (13;14;18;48;49) | 2p16.3 | 3 | 2 | 3 (0.69) | 1 (0.23) | - | 1 (0.28) |
| NTAN1 (52) | 16p13.1 | 0 | 4 | - | 3 (0.69) | - | 1 (0.28) |
| PGBD1 (41) | 6p22.1 | 0 | 0 | - | - | - | - |
| PI4KCA (47) | 22q11.21 | 2 | 1 | 2 (0.46) | - | - | 1 (0.28) |
| PRODH (37;38) | 22q11.21 | 11 | 23 | 9 (2.08) | 13 (3.0) | 2 (0.56) | 10 (2.82) |
| RAPGEF6 (15) | 5q31.1 | 0 | 0 | - | - | - | - |
| SLC1A3 (14) | 5p13.2 | 0 | 0 | - | - | - | - |
| SSTR5 (47) | 16p13.3 | 0 | 0 | - | - | - | - |
| TJP1 (48) | 15q13.1 | 0 | 0 | - | - | - | - |
| Total | 36 | 63 | 30 (6.9) | 35 (8.1) | 6 (1.7) | 28 (7.9) | |
| Del p = 0.0004 | Dup p = 1 | ||||||