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. Author manuscript; available in PMC: 2012 Jun 21.
Published in final edited form as: Biochemistry. 2010 Dec 21;50(2):230–239. doi: 10.1021/bi101401h

Table 4.

Concentrations of diamide required for 50% inhibition of catalytic activity.

Enzyme μM Diamidea Enzyme μM Diamide
IDH1/IDH2 500 -5IDH1/IDH2 160
IDH1G15D/IDH2 6.5 -5IDH1G15D/IDH2 7.5
-5IDH1D168K/IDH2 13.0
a

Values were determined from graphs presented in Figure 8.