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Relationship between CYP3A4 inhibitory activity and content in MeOH extract.
| IC50 (μg/ml) | Content (%) | |
|---|---|---|
| MeOH extract | 21 ± 1.8 | — |
| Hexane fraction | 14 ± 2.6 (11.3(a)) | 54.0 |
| Curdion | 3.9 ± 1.7 (2.4(a)) | 11.4 |
| Curcumin | >11.1 | 1.2 |
(a)Theoritical value calculated from the content in MeOH extract hypothesizing that curdion is the only component responsible for the CYP3A4 inhibitory activity of C. aromatica when the IC50 of MeOH extract is 21 μg/ml. Results are means ± SD from triplicate experiments.
