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In NB4 cells, PML-RARα expression leads to aberrant gene methylation by recruitment of DNMT1 and other chromatin modifiers. Both the PML-RARα and DNMT1 could be repressed either by THL or its active fraction EAS5, which resulted in apoptosis of leukemia cells. The arrow indicates promotion, and the T-shaped bar indicates repression. The data of THL are presented in Figure 6, and the data of EAS5 are presented in Figure 12.
