Table 3.
Comparison of Cohen-Mansfield agitation inventory (CMAI) total score between control and intervention (stepwise protocol for treatment of pain) groups using repeated measures analysis of covariance (ANCOVA)*
| Week | Mean (SD) CMAI total score | Effect of intervention on CMAI total† | Intracluster correlation coefficient‡ | ||
|---|---|---|---|---|---|
| Control group | Intervention group | Estimate (95% CI) | P value | ||
| 0 | 56.2 (16.1), n=177 | 56.5 (15.2), n=175 | — | — | 0.162 |
| 2 | 53.9 (17.0), n=161 | 52.0 (19.5), n=158 | −3.6 (−0.5 to −6.7) | 0.022 | 0.261 |
| 4 | 52.5 (16.3), n=160 | 49.4 (19.0), n=148 | −4.1 (−0.9 to −7.4) | 0.012 | 0.231 |
| 8 | 52.8 (16.8), n=157 | 46.9 (18.7), n=147 | −7.0 (−3.7 to −10.3) | <0.001 | 0.226 |
| 12 | 52.5 (16.0), n=152 | 50.3 (20.3), n=142 | −3.2 (0.1 to −6.4) | 0.058 | 0.253 |
*Baseline score as covariate and least squares weighted by number of patients within cluster; P value from multivariate test of intervention was 0.002, and cross effect between week and intervention was <0.001.
†Variable estimate by week of effect of intervention on CMAI score from estimated model.
‡Proportion of total variance between clusters, and measured within framework of ANCOVA.