Fig. 2.

Quantitative interaction networks of tyrosine kinases associated with the Erb family of receptors, which was determined using protein microarrays displaying 96 SH2 and 37 PTB domains. The SH2 and PTB protein domains were probed with fluorescently labeled phosphopeptides representing the different tyrosine phosphoryaltion sites on the Erb kinases. The readout of peptide binding was monitored and quantified by fluorescence. The interaction maps (bottom panel) were constructed from the quantitative interaction data (156). Reprinted from reference (156) with permission from Elsevier.