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. Author manuscript; available in PMC: 2011 Jul 18.
Published in final edited form as: Pigment Cell Melanoma Res. 2010 Dec;23(6):781–794. doi: 10.1111/j.1755-148X.2010.00773.x

Figure 4.

Figure 4

Histological characterization of pigmented lesions. (A) Scatter plot of p53 immunopositive cells in 25 TP-ras0/+ nevi, 12 TP-ras0/+ melanomas, 13 TP-ras0/+: Mdm4+/− nevi, and 4 TP-ras0/+: Mdm4+/− melanomas (>5 mm2) analyzed per field (0.5 mm2 area using 20× magnification). (B) Plot of tumor progression (based on size) in relation to degree of pigmentation of each pigmented lesion using the reference scale from 1 (highest, 100%) to 5 (lowest, 0–10%). A representative picture of hematoxylin and eosin (HE) sections of pigmented lesion scored by the degree of pigmentation (at the bottom).