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Synthesis of thymine-containing γPNA monomers. Reagents and conditions: (a) iBuOCOCl, NMM, DME, −20°C, then NaBH4/H2O, −20°C; (b) Nos-Gly-OEt, Ph3P, DIAD, THF, 0°C→RT; (c) PhSH, K2CO3, CH3CN, RT; (d) Thy-AcOH, DCC, DhbtOH, DMF, 40°C; (e) 2 M NaOH : THF (1 : 1), 15 min (0°C), then neutralized with 1 M HCl.
