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. Author manuscript; available in PMC: 2012 Jul 12.

Published in final edited form as: Circulation. 2011 Jul 12;124(2):225–235. doi: 10.1161/CIRCULATIONAHA.110.952648

Figure 1A: A diagram illustrating the surface bound complex enzymes of the “intrinsic” and “extrinsic” coagulation pathways. The surface bound complex of the intrinsic pathway is outlined by a dashed line. The amplification by thrombin feedback activations of fV, fVIII, fVII and fXI are also illustrated.

Figure 1B: Coagulation system regulation by the stoichiometric (AT and TFPI) inhibitors which down-regulate the system by binding the serine proteases and the dynamic APC system, which causes proteolytic inactivation the cofactors (fVa and fVIIIa). (Figure 1 from Mann KG. Thrombin Formation CHEST 2003; 124:4S–10S with permission)

Figure 1A: A diagram illustrating the surface bound complex enzymes of the “intrinsic” and “extrinsic” coagulation pathways. The surface bound complex of the intrinsic pathway is outlined by a dashed line. The amplification by thrombin feedback activations of fV, fVIII, fVII and fXI are also illustrated.

Figure 1B: Coagulation system regulation by the stoichiometric (AT and TFPI) inhibitors which down-regulate the system by binding the serine proteases and the dynamic APC system, which causes proteolytic inactivation the cofactors (fVa and fVIIIa). (Figure 1 from Mann KG. Thrombin Formation CHEST 2003; 124:4S–10S with permission)