Figure 3.

Figure 3A: Numerical simulations of1 the earliest events leading to catalyst formation with a Tf insult. The scale is logarithmic illustrating the initial activation over time of fV, fVIII and platelets by the thrombin initially produced (by fXa) in the reaction.

Figure 3B: The generation of thrombin, fVa and fVIIIa and platelet activation over the entire course of the reaction. The thrombin catalyzed feedback amplifications resulting in enhanced platelets and fVIII activation associated with the generation of increased amounts of thrombin by the prothrombinase complex are shown in this numerical simulation.