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. Author manuscript; available in PMC: 2012 Jul 12.
Published in final edited form as: Circulation. 2011 Jul 12;124(2):225–235. doi: 10.1161/CIRCULATIONAHA.110.952648

Table 1.

Meizothrombin Activity
Substrate Relative Activity (% α-IIa)*
Fibrinogen 7%A
Platelets 2%A
Factor V 41%B
Tm + Protein C 93%A
Tm + TAFI 10%A
Antithrombin 25%A
*

Based on comparison between r-wt-α-IIa and r(R155A, R271A, R284A)mIIa

A

Côté HCF, Bajzar L, Stevens WK, Samis JA, Morser J, MacGillivray RT, Nesheim ME J. Biol. Chem. 272:6194–6200, 1997

B

Orfeo T, Brufatto N, Nesheim ME, Xu H, Butenas S, Mann KG. J. Biol. Chem. 279: 19580–19591, 2004.