Table 1.
Phenotypes of synaptic function and synaptic plasticity of PSD-MAGUK mutant mice
PSD-95 [14,18] | PSD-93 [18] | SAP97 [39] | SAP102 [38] | |
---|---|---|---|---|
basal transmission | decreased/not affected | not affected | not affected | not affected |
Paired pulse ratio | enhanced | enhanced | n.a. | normal |
High frequency stim-LTP | enhanced | slightly decreased | n.a. | enhanced |
LTP saturation level | enhanced | n.a. | n.a. | n.a. |
Theta burst stim-LTP | enhanced | impaired | n.a. | n.a. |
5Hz-LTP (threshold) | enhanced | n.a. | n.a. | enhanced |
pairing LTP | enhanced | n.a. | not affected | n.a. |
Spike-timing-dependent-LTP 1AP pair 10Hz | enhanced | normal | n.a. | enhanced |
Spike-timing-dependent-LTP burst pair 10Hz | slightly enhanced | impaired | n.a. | normal |
Low frequency stim-LTD | deficient | normal | n.a. | n.a. |