Table 3.
Effects of intra-Str injections of muscimol and methyl l-DOPA on response parameters of MC-responsive GPe neurons
Muscimol (N = 6) |
Methyl-l-DOPA (N = 6) |
|||||
---|---|---|---|---|---|---|
Before | After | Before | After | |||
Average firing rate | 28.3 ± 5.8 | p < 0.02 | 42.4 ± 9.7 | 28.7 ± 8.6 | P < 0.05 | 40.6 ± 13.6 |
Burst index, % | 38.9 ± 13.5 | p < 0.001 | 17.1 ± 2.2 | 43.0 ± 8.2 | P < 0.005 | 25.9 ± 11.0 |
Early excitation, n | 6 | 6 | 6 | 1 | ||
Latency (ms) | 7.3 ± 1.0 | ns | 8.0 ± 1.7 | 7.3 ± 1.5 | —- | 8.2 |
Duration (ms) | 3.7 ± 0.8 | ns | 4.2 ± 0.9 | 3.5 ± 0.8 | —- | 5.2 |
Strength (spikes) | 14.6 ± 3.7 | ns | 21.5 ± 11.2 | 12.1 ± 2.6 | —- | 15.2 |
Short inhibition | 6 | 0 | 6 | 6 | ||
Latency | 15.0 ± 2.3 | 14.7 ± 1.5 | ns | 16.2 ± 2.0 | ||
Duration | 11.0 ± 4.6 | 14.2 ± 2.0 | P < 0.005 | 10.0 ± 1.1 | ||
Strength | 31.2 ± 8.4 | 40.3 ± 13.7 | ns | 38.1 ± 12.8 | ||
Late excitation | 6 | 6 | 6 | 6 | ||
Latency | 34.0 ± 4.3 | ns | 31.2 ± 8.4 | 34.2 ± 5.2 | ns | 38.7 ± 10.8 |
Duration | 80.0 ± 33.6 | p < 0.005 | 23.8 ± 8.9 | 153.2 ± 45.4 | P < 0.02 | 66.2 ± 38.3 |
Strength | 214.9 ± 102.7 | p < 0.02 | 100.5 ± 54.1 | 457.2 ± 189.8 | P < 0.02 | 222.2 ± 116.2 |
Statistics: Paired t test. ns, Not significant; —-, not compared.