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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Br J Haematol. 2010 Nov 29;152(2):155–163. doi: 10.1111/j.1365-2141.2010.08491.x

Figure 1.

Figure 1

Immunoprotesome expression level in MM patient tumor cells and MM cell lines and PR-924 inhibits growth and triggers apoptosis in MM. (A) Differential expression of immunoproteasome content in MM cell lines and MM patients purified CD138+ cells. (B) Human MM cell lines (MM.1S, MM.1R, RPMI-8226, KMS12, LR-5, DOX40, INA-6, OPM1 and OPM2) were treated with PR-924 (dose range: 1-20 μM) for 24h, 48h, and 72h; cell viability was measured using MTT assays. Data presented are mean plus or minus SD of three independent experiments (P <. 05 for all cell lines at different time points). (C) MM.1S and MM.1R cell lines were treated with PR-924 (3μM) for 48h, and apoptosis was measured using Annexin V/PI binding assay and FACS analysis (P < 0.05; n=3,). A representative graph from three independent experiments is shown.