Table 2.
Hazard ratio (HR) estimates and 95% confidence intervals (CIs) comparing mortality risk among cancer patients with antecedent deep venous thrombosis (DVT) versus cancer patients without a history of DVT
| No history of DVT (reference group) |
DVT at diagnosis* | DVT 1 yr before diagnosis† |
DVT 1–5 yrs before diagnosis |
DVT>5 yrs before diagnosis |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Cancer | N | N | HR (95%CI) | N | HR (95%CI) | N | HR (95%CI) | N | HR (95%CI) |
| Total | 401,547 | 845 | 1.38 (1.28–1.49) | 1,250 | 1.14 (1.07–1.22) | 3,347 | 1.14 (1.10–1.19) | 5,019 | 1.27 (1.23–1.31) |
| Larynx | 16,397 | 10 | 1.32 (0.63–2.77) | 22 | 1.56 (0.99–2.48) | 88 | 1.33 (1.02–1.65) | 160 | 1.18 (0.97–1.44) |
| Lung | 129,521 | 219 | 1.29 (1.12–1.48) | 267 | 1.20 (1.05–1.36) | 898 | 1.13 (1.07–1.20) | 1,391 | 1.21 (1.14–1.28) |
| Buccal | 34,463 | 31 | 1.22 (0.83–1.77) | 61 | 0.87 (0.64–1.17) | 254 | 1.03 (0.89–1.19) | 336 | 1.28 (1.13–1.45) |
| Esophagus | 12,170 | 16 | 0.97 (0.56–1.67) | 30 | 1.47 (1.01–2.13) | 73 | 1.16 (0.90–1.48) | 124 | 1.27 (1.05–1.54) |
| Gastric | 9,728 | 13 | 2.35 (1.33–4.14) | 23 | 1.88 (1.21–2.91) | 70 | 1.24 (0.96–1.60) | 107 | 1.18 (0.95–1.46) |
| Pancreas | 10,631 | 51 | 1.25 (0.93–1.67) | 29 | 1.32 (0.90–1.94) | 76 | 0.92 (0.73–1.17) | 115 | 1.64 (1.36–1.98) |
| Colorectal | 43,383 | 71 | 1.05 (0.80–1.39) | 122 | 1.28 (1.04–1.58) | 325 | 1.27 (1.12–1.44) | 490 | 1.33 (1.20–1.49) |
| Liver | 6,262 | 11 | 1.68 (0.93–3.03) | 14 | 0.89 (0.51–1.57) | 53 | 1.32 (1.00–1.76) | 75 | 1.19 (0.93–1.52) |
| Prostate | 77,238 | 140 | 1.34 (1.10–1.62) | 270 | 1.30 (1.12–1.50) | 622 | 1.11 (1.00–1.23) | 878 | 1.17 (1.07–1.28) |
| Bladder | 22,949 | 34 | 2.55 (1.77–3.67) | 58 | 0.68 (0.47–0.97) | 154 | 1.15 (0.94–1.41) | 218 | 1.21 (1.02–1.45) |
| Kidney | 10,799 | 21 | 1.95 (1.23–3.10) | 38 | 1.42 (1.23–2.06) | 68 | 1.35 (1.03–1.77) | 149 | 1.39 (1.13–1.72) |
| Non-Hodgkin lymphoma | 11,388 | 32 | 1.33 (0.91–1.94) | 50 | 1.32 (0.97–1.80) | 75 | 1.09 (0.83–1.42) | 129 | 1.36 (1.11–1.66) |
| Leukemia | 1,124 | 24 | 1.24 (0.77–1.99) | 43 | 1.19 (0.86–1.64) | 102 | 1.23 (1.00–1.53) | 155 | 1.37 (1.14–1.64) |
| Multiple myeloma | 5,404 | 8 | 1.15 (0.52–2.57) | 22 | 1.09 (0.69–1.74) | 58 | 1.02 (0.77–1.36) | 65 | 1.27 (0.95–1.69) |
All models are multivariable Cox regression models that include yes-no history of DVT, race (white Caucasian, African American), age (continuous), calendar period (<1985, ≥1985) and the number of hospital visits (continuous).
Underlined results were significant at p<0.05.
*
DVT diagnosed within the 3-month period prior to cancer diagnosis.
†
DVT diagnosed between 3 months and 1 year before cancer diagnosis.