Fig. 2.

1,25(OH)₂D₃ analog, RO26-2198 administered to NOD mice inhibits type 1 diabetes development. NOD mice were treated five times per week with vehicle (open circles) or with 0.03 μg/kg 1,25(OH)₂D₃ analog RO26-2198 from eight to 16 wk of age (black circles) or from eight to 12 wk of age (black squares). Note that the short course of treatment arrested the clinical onset of diabetes in the NOD mice. RO26-2198 did not induce hypercalcemia even after 40 administrations (data not shown). From Gregori et al. (68), with permission.