SB does not rescue the LQ acquisition deficit in ERαknockout (ERKO) females (mean ± sem). The LQ data from hormone-primed ERKO females and their WT littermates that were either SB treated (SB) or not treated (Cont) are shown. Four groups with 10 females in each were formed and tested for receptivity. A, Data over five trials are shown. B, Data from the final trial are presented. , WT SB; , WT Cont; , ERKO SB; ○--, ERKO Cont. *, Significantly different from own trial 1 baseline (P < 0.05); $, significantly different from all other groups (P < 0.05). #, significantly different from WT females (P < 0.05).