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. 2011 Jun 28;152(8):2996–3004. doi: 10.1210/en.2011-0281

Fig. 5.

Fig. 5.

Liver PGC-1α is not required for the induction of gluconeogenic expression in the liver. LoxP control and PGC-1α LKO mice were injected with 700 ng/g of FGF21 and gene expression was analyzed 4 h after injection. As a positive control the response in PGC-1α expression (panel A) and EGR1 (panel B) are shown. Significant increases in hepatic G6Pase (panel C), PEPCK (panel D), IGFBP1 (panel E), and IRS2 (panel F) expression in the PGC-1α LKO mice are shown. Data are shown as mean ± sem (*, P < 0.05; **, P < 0.00). Ctrl, Control.