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. 2011 Jun 21;152(8):3074–3081. doi: 10.1210/en.2011-1031

Fig. 1.

Fig. 1.

Targeted deletion of adipocytes in FAT-ATTAC mice. Six-week-old wild-type (wt) (n = 5) or FAT-ATTAC (n = 6) mice were subjected to AP20187 dimerizer treatment for 14 d. A, Body weights. B, Magnetic resonance imaging analysis from representative wild-type and FAT-ATTAC mice showing loss of fat signal. C, Weights of epididymal (eWAT) and inguinal (iWAT) white adipose tissue depots were taken. Data are expressed as mean ± sd; *, P < 0.01 wild type vs. FAT-ATTAC. D, Representative hematoxylin and eosin stains of epididymal and inguinal adipose depots. Scale bars, 50 μm. E, mRNA expression of adiponectin in epididymal and inguinal adipose depots. Data are expressed as mean ± sd; *, P < 0.01 wild type vs. FAT-ATTAC. F, Adiponectin serum samples from three representative wild-type and FAT-ATTAC mice were analyzed by Western blotting using an antiadiponectin antibody.