FIGURE 1.

Conservation of His residues in VWF and gel-forming mucins. Human VWF was aligned with VWF (A) or representative gel-forming mucins MUC2, MUC5AC, MUC5B, MUC6, MUC19, and FIMB1 (B) from the vertebrate species at the left of each graph. The positions of His residues in human VWF and their locations with domains D1, D2, D′, and D3 are indicated at the top. A square in the grid is colored when the aligned amino acid is His, as in human VWF, and white when it is not His. The color key indicates the percentage of sequence identity at that position from purple (0%) to red (100%).