FIGURE 4.

Structure-based alignment of the sequences of ClfB·ligand complexes and the ClfA·Fg γ-chain peptide complex. A, alignment of the amino acid sequences of the ligand molecules based on the structure of their complexes. Each of these amino acid-binding subsites within the binding site were designated 0–12 starting from the N terminus. The ClfB·K10 and ClfB·Fg α-chain peptide complexes and the ClfA·Fg γ-chain peptide complex were superimposed, and the aligned sequences are listed. B, table of the key ligand-binding residues in ClfB and the corresponding residues in ClfA.