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. 2011 May 19;286(29):25495–25504. doi: 10.1074/jbc.M110.210260

FIGURE 6.

FIGURE 6.

Hippocampal short-term synaptic plasticity is affected in Fmr1 KO mice. a, example single experiments (100-ms interpulse interval) showing short-term synaptic plasticity in response to a 10-pulse stimulus train (arrowheads). EPSC trains are the averaged responses from 20 sweeps (stimulus artifacts truncated). b, averaged synaptic facilitation during the stimulus train. Each point represents the averaged EPSC amplitude from all 10 pulses, normalized to the amplitude of the first EPSC in the train (bars show average (Train avg) S.E.). c–e, facilitation is reduced in Fmr1 KO mice, with low frequency synaptic input. Interpulse intervals are as follows: 100 (c), 70 (d), and 50 (e) ms. Each point shows the EPSC amplitudes, averaged from 20 sweeps, normalized to the amplitude (Amp (Norm)) of the first EPSC (*, p < 0.05; **, p < 0.01; bars show S.E.).