FIGURE 6.

Knockdown of VLDLR blocks accumulation of viral RNA in RV1B-infected cells. HeLa cells were transfected with control siRNA or siRNA targeting VLDLR or LRP5 as indicated. A–C, at 48 h after the transfection, cells were mock infected or infected with RV16 or RV1B for an additional 24 h. VLDLR and LRP5 were detected by Western blotting in mock-infected cells (A). RNA levels of RV16 (B) or RV1B (C) were determined by real-time PCR.