TABLE 1.
miRNA induced by RIG-I-mediated signaling
HeLa cells stably expressing FK/RIG were treated with AP for the periods indicated and miRNA expression was determined by miRNA microarray (TORAY). The relative expression (fold-increase compared to the baseline miRNA level at 0 h) of representative miRNA whose expression was up-regulated more than 2-fold is shown. The opposite strand of miRNA is denoted with an asterisk (*).
| AP20187 treatment (FK/RIG-HeLa cells) |
|||||
|---|---|---|---|---|---|
| 0 h | 3 h | 6 h | 9 h | 12 h | |
| miR-423–3p | 1.00 | 2.31 | 2.77 | 4.34 | 4.59 |
| miR-301b | 1.00 | 2.31 | UDa | UD | UD |
| miR-923 | 1.00 | 3.63 | 1.34 | 1.50 | 0.84 |
| miR-181a* | 1.00 | UD | 7.16 | UD | UD |
| miR-23b | 1.00 | 1.47 | 2.32 | 1.03 | 1.27 |
| miR-125b | 1.00 | 1.94 | 2.73 | 1.16 | 1.38 |
| miR-505* | 1.00 | UD | 2.41 | UD | UD |
| miR-940 | 1.00 | UD | 2.11 | UD | UD |
| miR-1226 | 1.00 | 0.90 | 2.05 | UD | UD |
| miR-1229 | 1.00 | UD | 2.80 | UD | UD |
| miR-1281 | 1.00 | UD | 2.21 | UD | UD |
| miR-149 | 1.00 | UD | 0.99 | 3.36 | UD |
| miR-188–5p | 1.00 | 1.85 | 1.36 | 3.70 | UD |
| miR-320 | 1.00 | 1.22 | 1.31 | 2.62 | 1.71 |
| miR-200c | 1.00 | 1.20 | 1.03 | 2.63 | UD |
| miR-362–5p | 1.00 | 1.09 | 0.94 | 5.65 | UD |
| miR-425* | 1.00 | UD | UD | 8.81 | UD |
| miR-769–3p | 1.00 | 1.00 | 1.01 | 2.65 | UD |
| miR-801 | 1.00 | 1.09 | 0.92 | 9.18 | 1.27 |
| miR-29b-1* | 1.00 | 1.43 | 1.27 | 2.00 | UD |
| miR-92b* | 1.00 | 0.70 | 0.88 | 2.29 | UD |
| miR-1225–3p | 1.00 | UD | UD | 7.16 | UD |
| miR-1228 | 1.00 | UD | 1.24 | 5.77 | UD |
| miR-1249 | 1.00 | UD | UD | 5.89 | UD |
| miR-1280 | 1.00 | 0.63 | 1.19 | 8.00 | 1.74 |
| miR-664 | 1.00 | 1.55 | UD | 23.75 | UD |
| miR-664* | 1.00 | 1.55 | UD | 22.62 | UD |
| miR-19b | 1.00 | 1.26 | 1.40 | 1.14 | 2.05 |
| miR-7i | 1.00 | 1.42 | 1.50 | 1.68 | 2.92 |
| miR-484 | 1.00 | 0.84 | 1.38 | 1.67 | 2.04 |
| miR-500* | 1.00 | 1.58 | 1.76 | 1.73 | 3.18 |
| miR-421 | 1.00 | 1.61 | 1.90 | 0.96 | 2.11 |
| miR-671–5p | 1.00 | UD | UD | UD | 5.38 |
| miR-768–5p | 1.00 | 0.61 | 0.57 | UD | 2.94 |
| miR-939 | 1.00 | 0.79 | 0.71 | UD | 2.75 |
| miR-320b | 1.00 | 1.39 | 1.44 | 1.92 | 2.20 |
| miR-1304 | 1.00 | 1.69 | 1.9 | UD | 31.12 |
a UD, undetermined.