Table 3.
Adjusted hazard ratios for death used in the two prognostic models: CD4 model and total lymphocyte count/haemoglobin (TLC/Hb) model.
| CD4 model | TLC/Hb model | |
|---|---|---|
| Age ≥ 40 years (v. < 40 years) | ||
| <40 (reference) | 1 | 1 |
| ≥40 | 1.43 (1.23–1.66) | 1.36 (1.12–1.64) |
| Sex | ||
| Male (reference) | 1 | 1 |
| Female | 0.68 (0.58–0.79) | 0.60 (0.50–0.73) |
| Clinical stage* | ||
| Less advanced (reference) | 1 | 1 |
| Advanced | 2.72 (1.87–3.95) | 2.96 (1.83–4.78) |
| CD4 count (cells/μL) | ||
| <25 (reference) | 1 | |
| 25–49 | 0.76 (0.62–0.94) | |
| 50–99 | 0.46 (0.38–0.57) | |
| 100–199 | 0.35 (0.28–0.42) | |
| ≥200 | 0.29 (0.22–0.38) | |
| Weight (kg) | ||
| <45 (reference) | 1 | 1 |
| 45–49 | 0.59 (0.48–0.72) | 0.61 (0.47–0.79) |
| 50–59 | 0.40 (0.33–0.48) | 0.40 (0.32–0.51) |
| ≥60 | 0.24 (0.19–0.30) | 0.25 (0.19–0.33) |
| Total lymphocyte count (cells/μL) | ||
| 0–799 (reference) | 1 | |
| 800–1199 | 0.71 (0.55–0.91) | |
| ≥1200 | 0.53 (0.43–0.65) | |
| Categories of anaemia† | ||
| Severe (reference) | 1 | |
| Moderate | 0.71 (0.56–0.91) | |
| Mild or none | 0.47 (0.37–0.61) | |
Results from Weibull models adjusted for all variables shown, based on 10,331 patients remaining in care, with missing values imputed.
Less advanced=WHO stage I or II, advanced=WHO stage III or IV
Severe=haemoglobin <8 g/dL, moderate=haemoglobin 8–10 g/dL in females and 8–11 g/dL in males, mild=haemoglobin 10–12 g/dL in females and 11–13 g/dL in males; none=haemoglobin >12 g/dL in females and >13 g/dL in males