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. Author manuscript; available in PMC: 2011 Jul 18.
Published in final edited form as: Oncogene. 2010 Jan 18;29(14):2047–2059. doi: 10.1038/onc.2009.486

Figure 1.

Figure 1

Tyrosine kinase B (TrkB) is over-expressed in human head and neck squamous cell carcinoma (HNSCC) tumors. (a) Complementary DNA (cDNA) microarray analysis revealed that messenger RNA (mRNA) expression of NTRK2 correlated with expression of BDNF in 71 previously untreated human tumors (P<0.005) (b) Expression of TrkB and brain-derived neurotrophic factor (BDNF) in representative samples on a human HNSCC tissue array. Tumors were analyzed and graded for TrkB (P<0.0001) and BDNF (P<0.001) expression (scale: 0–3). (c) Protein lysates from subconfluent HNSCC or normal cell lines were separated by SDS–PAGE and assessed with the indicated antibodies. Mouse brain (MsBr) was used as a positive control for TrkB expression. (d) Schematic representation of the TrkB receptor. Exon numbers indicate regions of the receptor that were assessed for genomic mutational analysis (see Table 1). TM, transmembrane domain; TK, tyrosine kinase.