Table 3.
Estimated Four-year Incidence of Age-Related Macular Degeneration (AMD) Lesions in the First, Second and Either eye, Stratified by Specific Lesions Present at Baseline
| Incidence in 1st Eye |
Incidence in 2nd Eye |
Incidence in Either Eye |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| N | n | % (CI) | N | n | % (CI) | N | n | % (CI) | |
| Drusen size (diameter)† | |||||||||
| <63 μm | 152 | 93 | 61.2 (53.0, 69.0) | 787 | 452 | 57.4 (53.9, 60.9) | 939 | 547 | 57.9 (54.7, 61.1) |
| ≥63 μm, <125 μm | 2282 | 420 | 18.4 (16.8, 20.1) | 1058 | 216 | 20.4 (18.0, 23.0) | 3340 | 636 | 19.0 (17.7, 20.4) |
| ≥125 μm, <250 μm | 3152 | 203 | 6.4 (5.6, 7.4) | 584 | 53 | 9.1 (7.0, 11.7) | 3736 | 256 | 6.9 (6.1, 7.7) |
| ≥ 250 μm | 3577 | 57 | 1.6 (1.2, 2.1) | 303 | 14 | 4.6 (2.5, 7.6) | 3880 | 71 | 1.8 (1.4, 2.3) |
| Drusen type | |||||||||
| Soft distinct | 2829 | 290 | 10.3 (9.2, 11.4) | 749 | 87 | 11.6 (9.4, 14.1) | 3578 | 379 | 10.5 (9.5, 11.6) |
| Soft indistinct | 3459 | 77 | 2.2 (1.8, 2.8) | 372 | 26 | 7.0 (4.6, 10.1) | 3831 | 103 | 2.7 (2.2, 3.3) |
| Any pigment abnormality | 3553 | 80 | 2.3 (1.8, 2.8) | 320 | 11 | 3.4 (1.7, 6.1) | 3873 | 91 | 2.3 (1.9, 2.9) |
| Increased retinal pigment | 3145 | 101 | 3.2 (2.6, 3.9) | 525 | 14 | 2.7 (1.5, 4.4) | 3670 | 118 | 3.1 (2.6, 3.7) |
| RPE depigmentation | 3419 | 66 | 1.9 (1.5, 2.4) | 330 | 9 | 2.7 (1.3, 5.1) | 3749 | 75 | 1.9 (1.5, 2.4) |
| Geographic atrophy | 3702 | 5 | 0.1 (0.0, 0.3) | 149 | 0 | * | 3851 | 5 | 0.1 (0.0, 0.3) |
| Pure geographic atrophy | 3882 | 3 | 0.1 (0.0, 0.2) | 24 | 0 | * | 3906 | 3 | 0.1 (0.0, 0.2) |
| Exudative AMD | 3707 | 5 | 0.1 (0.0, 0.3) | 146 | 0 | * | 3853 | 5 | 0.1 (0.0, 0.3) |
N=number at risk at baseline, n=number of incident cases, CI=confidence interval, RP=retinal pigment epithelium.
*
No incident cases.
†
Incidence refers to the presence of drusen of a specific size at follow-up when at baseline there was no evidence of drusen of that size in the same eye although drusen of a different size may be present.