Table 8.
Estimated Annual Incidence of Early and Advanced Age-Related Macular Degeneration (AMD) Defined by the Wisconsin AMD Definitions in Population-Based Studies
| Age at baseline (years) | Annual Incidence by Population-Based Studies | |||||
|---|---|---|---|---|---|---|
| LALES | BDES | BMES | ||||
| N | % (CI) | N | % (CI) | N | % (CI) | |
| Earlv AMD | ||||||
| 43–54 | 1728 | 0.48 (0.15, 0.80) | 1135 | 0.78 (0.27, 1.29) | 332 | 0.54 (0.00, 1.32) |
| 55–64 | 873 | 0.55 (0.06, 1.04) | 855 | 0.94 (0.30, 1.59) | 838 | 0.93 (0.28, 1.58) |
| 65–74 | 473 | 1.65 (0.50, 2.80) | 660 | 3.22 (1.90, 4.57) | 759 | 2.40 (1.31, 3.49) |
| ≥ 75 | 112 | 2.45 (0.00, 5.31) | 184 | 4.56 (1.50, 7.57) | 269 | 3.94 (1.62, 6.26) |
|
| ||||||
| Overall | 3186 | 0.75 (0.45, 1.05) | 2834 | 1.64 (1.20, 2.11) | 2198 | 1.50 (0.99, 2.01) |
|
| ||||||
| Advanced AMD | ||||||
| 43–54 | 1817 | 0.03 (0.00, 0.10) | 1254 | * | 334 | * |
| 55–64 | 985 | * | 1033 | 0.06 (0.00, 0.21) | 847 | 0.02 (0.00, 0.13) |
| 65–74 | 533 | 0.15 (0.00, 0.48) | 901 | 0.26 (0.00, 0.59) | 810 | 0.20 (0.00, 0.50) |
| ≥ 75 | 150 | 0.68 (0.00, 1.99) | 314 | 1.08 (0.00, 2.22) | 322 | 0.99 (0.00, 2.08) |
|
| ||||||
| Overall | 3485 | 0.05 (0.00, 0.12) | 3502 | 0.18 (0.00, 0.32) | 2313 | 0.16 (0.00, 0.32) |
LALES=Los Angeles Latino Eye Study, BDES=Beaver Dam Eye Study, BMES=Blue Mountains Eye Study.
N=number at risk at baseline, stratified by age-groups different from usual LALES format to allow uniformity across studies. For early AMD, 18 persons aged 40–42 were excluded from the LALES at-risk group. For advanced AMD, 192 persons were excluded. Incidence data presented as percent (95% confidence interval). Annual incidence estimated from 4-year incidence for LALES, and 5-year incidence for BDES and BMES.
No incidence cases.
Note: The Wisconsin AMD definitions: Incidence of early AMD defined as absence of AMD lesions in both eyes at baseline and presence of either soft indistinct or reticular drusen or the co-presence of any drusen and retinal pigmentary abnormalities in either or both eyes at follow-up. Incidence of advanced AMD defined as absence of AMD lesions in both eyes at baseline and presence of exudative AMD or geographic atrophy in either or both eyes at follow-up. If definitions other than the Wisconsin system are used, incidence rates may differ.