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. Author manuscript; available in PMC: 2012 Jun 28.
Published in final edited form as: Biochemistry. 2011 Jun 6;50(25):5767–5779. doi: 10.1021/bi2005416

Figure 4.

Figure 4

A comparison of the amino acid sequences for wildtype Tbb TIM and the engineered monoTIM. The first amino acid residue in loop 3 that follows β-strand 3 is Gln-65. Residues 69 – 79 (red) from loop 3 were replaced by four amino acids (N A D A) that extend the β-strand 3 by one turn. Additional amino acid substitutions for the wildtype enzyme are shown in blue.