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. Author manuscript; available in PMC: 2011 Jul 18.
Published in final edited form as: J Invest Dermatol. 2011 Feb 10;131(6):1384–1387. doi: 10.1038/jid.2011.21

Figure 2. Comparative histopathology of murine and human epidermal melanomas.

Figure 2

(a) Hematoxylin and eosin (H&E)-stained section showing a deep dermal malignant melanoma (MM) in an Arf−/−::Tyr-Nras mouse. The yellow arrow denotes a nodular melanoma composed of sheets of pleomorphic melanocytes (MCs). This nodular lesion is clearly separated from the epidermis by layers of collagen. (b) MM from an Arf−/−::Tyr-Nras::K14-Kitl mouse. Dotted yellow arrow denotes atypical MCs in the epidermis, and filled yellow arrow atypical MCs in the dermis. There is an increased number of MCs, varying in size and shape, not only at the dermoepidermal junction but also at all levels of the epidermis. (c) Human superficial spreading MM. Dotted yellow arrow denotes atypical MCs in the epidermis, and filled yellow arrow atypical MCs in the dermis. The morphological similarities between Figure 2b and c are striking. Scale bars = 100 μM.