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Summary of important biochemical pathways for statins and their reported mechanisms of action. Text boxes indicate potential mechanisms of action for the benefit of statins. eNOS indicates endothelial nitric oxide synthase; HMG-CoA, 3-hydroxy-3-methylglutaryl–coenzyme A; NMDA, N-methyl-d-aspartate; Rho GTPase, Rho family of guanosine triphosphatases; and tPA, tissue plasminogen activator.
