Table 2.

BC Characteristics and Treatment in HL Survivors and Matched Patients With Sporadic BC

Characteristic	HL Survivors		Sporadic BC		P
	No.	%	No.	%
Stage
0	43	17	92	12	< .001
I	112	44	222	30
II	61	24	201	27
III	28	11	116	16
IV	4	2	33	4
Unknown	5	2	77	10
No. of positive lymph nodes
0	147	58	384	52	< .001
1-3	37	15	163	22
4-9	17	7	73	10
≥ 10	7	3	50	7
Unknown	45	18	71	10
Laterality at diagnosis
Unilateral	234	92	717	97	< .01
Bilateral	14	6	15	2
Unknown	5	2	9	1
Histology
Ductal carcinoma in situ	43	17	92	12	NS
Invasive ductal carcinoma	179	71	558	75
Invasive lobular carcinoma	14	5	39	5
Other/unknown	17	7	52	7
Extensive intraductal component
No	125	49	348	47	NS
Yes	44	17	108	15
Unknown	84	33	285	38
Multifocal disease
No	115	45	358	48	NS
Yes	52	21	179	24
Unknown	87	34	204	28
Type of surgery
Lumpectomy	59	23	406	55	< .001
Unilateral mastectomy	120	47	212	29
Bilateral mastectomy	60	24	29	4
Other/no surgery/unknown	14	6	94	13
Surgical margins
Negative: > 3 mm	174	69	473	64	< .05
Close: 1-3 mm	32	13	74	10
Positive: < 1 mm	4	2	39	5
Unknown	43	17	155	21
Hormone receptor status
Negative	72	28	155	21	NS
Positive	112	44	374	50
Unknown	69	27	212	29
HER2 status
Negative	71	28	206	28	NS
Positive	21	8	95	13
Unknown	161	64	440	59
Location
Upper outer quadrant	108	43	254	34	< .001
Upper inner quadrant	26	10	54	7
Lower outer quadrant	10	4	63	9
Lower inner quadrant	10	4	29	4
Central	20	8	33	4
Multiple quadrants	16	6	109	15
Other/unknown	63	25	99	7
Method of detection
Patient detected	103	41	404	55	< .01
Clinical exam	23	9	42	6
Screening mammogram	102	40	242	33
Other or unknown	25	10	53	7
Menopausal status
Premenopausal	124	49	508	69	< .001
Peri- or postmenopausal	91	36	188	25
Unknown	38	15	45	6
Family history of BC
None	173	68	545	74	< .001
First-degree relative	43	17	147	20
Unknown	37	15	49	7
Any chemotherapy*
Yes	119	47	447	60	< .001
No	113	45	260	35
Unknown	21	8	34	5
Any hormonal therapy*
Yes	89	35	348	47	< .01
No	125	49	309	42
Unknown	39	15	84	11
Any radiation therapy*
Yes	20	8	454	61	< .001
No	218	86	241	33
Unknown	15	6	46	6

Abbreviations: BC, breast cancer; HER2, human epidermal growth factor receptor 2; HL, Hodgkin's lymphoma; NS, not statistically significant.

^*Chemotherapy, hormonal therapy, or radiation therapy for treatment of breast cancer.