Table 4.
Characteristic | Contralateral BC |
Death As a Result of Any Cause |
||||
---|---|---|---|---|---|---|
Adjusted HR | 95% CI | P | Adjusted HR | 95% CI | P | |
HL history | ||||||
HL survivor | 4.3 | 1.7 to 11.0 | < .01 | 1.9 | 1.1 to 3.3 | < .05 |
Sporadic BC | Reference | Reference | ||||
Stage | ||||||
DCIS or stage I | Reference | Reference | ||||
Stages IIA-IV | 0.8 | 0.3 to 2.6 | NS | 4.0 | 2.1 to 7.6 | < .001 |
Unknown | 1.1 | 0.2 to 6.5 | NS | 1.7 | 0.5 to 6.5 | NS |
Regional lymph node involvement | ||||||
Negative | Reference | Reference | ||||
Positive | 1.2 | 0.4 to 3.8 | NS | 1.1 | 0.6 to 2.0 | NS |
Unknown | 1.4 | 0.5 to 4.2 | NS | 2.7 | 1.2 to 5.9 | < .05 |
Type of surgery | ||||||
Lumpectomy | Reference | Reference | ||||
Unilateral mastectomy | 0.2 | 0.1 to 0.7 | < .01 | 1.2 | 0.7 to 2.1 | NS |
Bilateral mastectomy | — | — | — | 1.2 | 0.4 to 3.1 | NS |
Other/none/unknown | 2.2 | 0.4 to 11.7 | NS | 3.5 | 1.0 to 12.2 | < .05 |
Surgical margins | ||||||
Negative | Reference | Reference | ||||
Positive | 1.6 | 0.5 to 5.0 | NS | 2.4 | 1.3 to 4.4 | < .01 |
Unknown | 0.9 | 0.3 to 3.0 | NS | 1.5 | 0.8 to 2.9 | NS |
Any chemotherapy* | ||||||
No | Reference | Reference | ||||
Yes | 1.0 | 0.4 to 2.6 | NS | 1.6 | 0.8 to 2.8 | NS |
Any hormonal therapy* | ||||||
No | Reference | Reference | ||||
Yes | 1.2 | 0.5 to 3.2 | NS | 0.8 | 0.5 to 1.3 | NS |
Any radiation* | ||||||
No | Reference | Reference | ||||
Yes | 0.7 | 0.3 to 1.9 | NS | 0.9 | 0.5 to 1.5 | NS |
Method of detection | ||||||
Screening mammogram | 1.2 | 0.5 to 2.9 | NS | 0.5 | 0.3 to 0.8 | < .05 |
Other | Reference | Reference | ||||
Menopausal status | ||||||
Premenopausal | Reference | Reference | ||||
Peri- or postmenopausal | 0.7 | 0.2 to 2.7 | NS | 2.8 | 1.2 to 6.4 | < .05 |
Unknown | 5.2 | 0.8 to 35.8 | NS | 1.6 | 0.8 to 3.4 | NS |
Family history of breast cancer | ||||||
None | Reference | Reference | ||||
First-degree relative | 2.7 | 1.1 to 6.4 | < .05 | 0.9 | 0.5 to 1.6 | NS |
Unknown | 2.0 | 0.5 to 7.2 | NS | 1.1 | 0.5 to 2.2 | NS |
Abbreviations: BC, breast cancer; DCIS, ductal carcinoma in situ; HL, Hodgkin's lymphoma; HR, hazard ratio; NS, not statistically significant.
Chemotherapy, hormonal therapy, or radiation therapy for treatment of breast cancer.