TABLE 2.
Summary of 14C mass balance, concentration maxima (Cmax, % dose/L), time to maxima (Tmax, d) in plasma (% dose/L), RBC (% dose/L), urine (% dose/collection), and feces (% dose/collection)1
| Total eliminated |
Total retained |
|||||
| Variables | Collection duration | Plasma | RBC | Urine | Feces | Body (mass balance)2 |
| % of dose | ||||||
| Present study: RRR-α-tocopherol | 21 d urine, 21 d feces | 4.26 ± 1.38 | 23.2 ± 5.8 | 72.5 ± 5.5 | ||
| Prior study: RRR-α-tocopherol (26) | 8 d urine, 7 d feces | – | – | 6.32 | 27.9 | 65.8 |
| Prior study: all-rac-α-tocopherol (26) | 8 d urine, 7 d feces | – | – | 16.5 | 31.5 | 52.0 |
| Prior study: all-rac-α-tocopherol (28) | 12 d urine, 12 d feces | – | – | <6.00 | 27.6 | 66.4 |
| Prior study: all-rac-α-tocopherol (29) | 3 d urine, 6 d feces | – | – | 8.21 | 31.4 | 60.4 |
| Cmax, | % dose/L | % dose/collection | ||||
| Present study: RRR-α-tocopherol | 5.39 ± 1.58a | 1.59 ± 0.31b | 0.72 ± 0.41c | 10.2 ± 3.64d | – | |
| Prior study: RRR-α-tocopherol (21) | 5.92 ± 1.90 | 1.09 ± 0.32 | – | – | – | |
| Tmax | d | |||||
| Present study: RRR-α-tocopherol | 0.58 ± 0.17e | 0.94 ± 0.13f | 1.42 ± 1.12g | 2.12 ± 0.77h | – | |
| Prior study: RRR-α-tocopherol (21) | 0.53 ± 0.24 | 1.06 ± 0.41 | – | – | – | |
1
Values are mean ± SD. Letters indicate that the labeled means differ: a-b, c-d < 0.0001; e-f, g-h P < 0.0002.
2
Mass balance (%) = 100 – 4.26 (urine) – 23.2 (feces).