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. 2011 Jun 5;2011:617438. doi: 10.1093/ecam/neq001

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Copyright © 2011 Nanako Sato et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chinpi had no therapeutic efficacy on demyelination in FcRγ/Fyn double-deficient mice (dKO). (A) Luxol Fast Blue (LFB) staining of cross-sections of the corpus callosum from untreated dKO mice (a), dKO mice after treatment with Chinpi for 2 month (b) and 3-month-old control mice (c). cc, corpus callosum; LV, lateral ventricle; GPI, globus pallidus (lateral segment); CP, caudate putamen; fi, fimbria; CA3, field CA3 in the hippocampus; int, internal capsule. (B) Immunoblot analysis of MBP and P-MBP levels from myelin in FcRγ/Fyn double-deficient (dKO) mice after treatment with Chinpi for 2 months. (a) Untreated control, (b) Chinpi treatment, (c) Normal control mice (3-months old).