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. 2011 Aug 1;124(15):2622–2630. doi: 10.1242/jcs.084798

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© 2011.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 7. — Co-dependent localisation of DILA–FLAG and UNC–GFP. (A–F) Larval Ch neurons. (A) The UNC–GFP fusion protein (green) is detected in the region just above the distal basal body, as marked by Sas-4 expression (magenta). This is predicted to be the transition zone. (B) UNC–GFP in wild-type flies, co-stained with anti-HRP (magenta). (C) In dila⁸¹ mutants, UNC–GFP is absent. (D) In unc²⁴ mutants, DILA–FLAG staining is weak and diffuse, with little detectable in the basal body region (compare with Fig. 5B), except for some abnormal aggregations in one dendrite. By contrast, Sas-4 is still localised in dila (E) and unc (F) mutants. (G) The uncoordinated phenotype of the weak hypomorph dila²⁴⁴ is enhanced after mutation of one copy of unc. The phenotype was scored according to three classes of increasing severity of uncoordination (see Materials and Methods). The difference in distributions is significant according to a χ-squared test, P<0.001.