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Regulation of contact inhibition of locomotion by microtubule remodelling. A normal polarised migrating cell has growing stable microtubules protruding into the leading edge lamella. Upon contact with another cell, microtubules close to the contact site become less stable and colliding cells switch their front–rear polarity. Microtubules might stabilise to another location in the cell body to reinforce the new leading edge, and the cell renews migration in the opposite direction.
