Table 1.
Anti-inflammatory effect of topically applied NDGA on TPA-induced morphological changes in skin as measured by number of epidermal layers, leukocyte infiltration and intercellular edema.
| Group | Observation | ||
|---|---|---|---|
| No. of epidermal layers | Leukocyte infiltration | Intercellular edema | |
| I (Ac/Ac) | 2-3 | − | − |
| II (Ac/TPA) | 4–6 | +++ | +++ |
| III [NDGA [15]/TPA] | 3-4 | + | + |
| IV [NDGA [25]/TPA] | 3-4 | +/− | − |
| V [NDGA [15]/Ac] | 2-3 | − | − |
| VI [NDGA [25]/Ac] | 2-3 | − | − |
Leukocytes infiltration and intensity of edema are indicated by slight (+), moderate (++), severe (+++), equivocal (+/−) while (−) indicates absence of any significant change. Ac: acetone; NDGA: nordihydroguaiaretic acid; TPA: 12-O-tetradecanoylphorbol-13-acetate.