Table 4.

Multivariate Cox Regression Analysis

Variable	Reduced Model		Full Model
	HR	95% CI	HR	95% CI
Age ≥ 45 years	1.26	0.86 to 1.86	1.12	0.75 to 1.68
Male sex	1.75	1.20 to 2.54	1.74	1.19 to 2.53
Grade IV	2.80	1.82 to 4.29	2.93	1.89 to 4.54
No. of prior progressions ≥ 2	1.23	0.88 to 1.73	1.28	0.91 to 1.80
KPS < 90	1.78	1.27 to 2.48	1.72	1.22 to 2.41
Exercise behavior ≥ 9 MET-h/wk	—		0.64	0.46 to 0.91

Abbreviations: HR, hazard ratio; KPS, Karnofsky performance status; MET, metabolic equivalent.