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. 2011 Jul 18;6(7):e21417. doi: 10.1371/journal.pone.0021417

Figure 3. Metabolic alterations in prostate cancer cell lines.

Figure 3

A) Heat map showing 29 named differential metabolites in prostate cancer cells relative to benign cell line (p<0.05, FDR = 20%), derived using a t-test coupled with permutations (n = 1,000) to determine the p-values for comparing the groups. The heat map was generated after log scaling and quantile normalization of the data. The color scheme is the same as in Fig. 2A . B) same as in (A) but for 52 named differential metabolites between ARI (yellow bar) and ARD (red bar) prostate cancer cells. C) Network view of the molecular concept analysis for the metabolomic profiles of our “altered in PCa cell line signature” (grey node). Each node represents a molecular concept or a set of biologically related genes. The node size is proportional to the number of genes in the concept. Each edge represents a statistically significant enrichment (FDR q-value<0.2). Enriched concepts describing “amino acid metabolism” are indicated by yellow bridges.