Table 8.

Interactions between Different Enzymes within the Same Pathway

Consecutive enzymes (3 pairs):

Glycoprotein biosynthesis:

RHK1 (putative Dol-P-Man dependent alpha(1-3) mannosyltransferase ⇔ oligosaccharyl transferase glycoprotein complex

Pyrimidine metabolism:

UPRTase ⇔ Uridine kinase

Oxidative phosphorylation:

ATP synthase subunit h ⇔ COX5B (Cytochrome-c oxidase chain Vb)

1 enzymatic step apart (3 pairs):

Glycoprotein biosynthesis:

dolichol-P-glucose synthetase ⇔ ... ⇔ components of oligosaccharyl transferase glycoprotein complex

Pyruvate metabolism:

carbon-catabolite sensitive malate synthease ⇔ ... ⇔ pyruvate carboxylase isozymes

Oxidative phosphorylation:

ATP synthase subunit h ⇔ ... ⇔ Ubiquinol cytochrome-c reductase subunit 8

2 enzymatic steps apart (1 pair):

Starch and sucrose metabolism:

Hexokinase B ⇔ ... ⇔ ... ⇔ multifunctional trehalose-6-phosphate synthase/phosphatase complex