Figure 2. Regulated pathways in liver tissue between ontogenetic stages and maternal diets.

Listed pathways between stages in AP offspring (white boxes) indicate the appropriate ontogenetic development, which doesn't occur in HP offspring (black boxes) at the corresponding developmental period. Pathways between the HP stages indicate processes and metabolic regulations, which occur in the HP offspring but not in the AP offspring in the corresponding developmental period. The differences in gene regulation dependent on diet and ontogenetic stage indicate fetal programming in terms of developmental and metabolic disorders (arrows between boxes show direction of the comparisons; small arrows to top = up-regulated, small arrows to bottom = down-regulated pathways; mTOR, mammalian target of rapamycin; RAN, Ras-related nuclear protein; IGF-1, insulin-like growth factor; PPAR, peroxisome proliferator receptor; AMPK, AMP-activated kinase).