Table 2. Significantly regulated transcripts of metabolic pathways in liver tissue between two ontogenetic stages within one dietary group (Ingenuity Pathway Analysis).
| Ontogenetic comparison | Diet | Regulated pathway | Regulation | No. of regulated genes | Genes involved in pathway | P value |
| 94 dpc vs. 1 dpn | AP | mTOR signaling | up | 3.42*E-3 | 9 | EIF3I, GNB1L, INSR, MRAS, PRKAA1, PRKCB, RHOG, RHOU, VEGFB |
| AP | RAN signaling | down | 1.43*E-2 | 3 | KPNA6 RANBP2 TNPO1 | |
| HP | Glucocorticoid receptor signaling | up | 4.44*E-3 | 13 | A2M, ERCC3, ESR1, GTF2H3, HMGB1, HSPA1B, MAPK9, PIK3C2A, TAF2, PIK3R1, PIK3R3, PRKACB, PTGES3 | |
| HP | RAN signaling | up | 4.93*E-3 | 3 | CSE1L, KPNA3, TNPO1 | |
| HP | IGF-1 signaling | down | 2.13*E-3 | 6 | FOS, IGFBP3, JUN, PIK3C2B, YWHAB, YWHAE | |
| HP | Biosynthesis of steroids | down | 1.02*E-2 | 3 | DHCR7, MVK, PMVK | |
| HP | Growth hormone signaling | down | 1.33*E-2 | 4 | FOS, IGFBP3, PIK3C2B, SOCS4 | |
| 1 dpn vs. 28 dpn | AP | AMPK Signaling | up | 1.89*E-4 | 9 | AK1, AK7, AKT3, HMGCR, IRS1, MAPK14, PRKAA2, PRKAB2, PRKAG2 |
| AP | Val, Leu, Ile degradation | up | 3.87*E-3 | 5 | ABAT, ACAT1, BCKDHA, HMGCS1, IVD | |
| AP | Oxidative phosphorylation | down | 2.19*E-3 | 8 | ATP6V0E2, ATP7B, COX17, COX10, NDUFA1, NDUFB6, NDUFS8, TCIRG1 | |
| HP | Oxidative phosphorylation | up | 3.70*E-4 | 11 | ATP6V1D, ATP6V1F, ATP6V1H, NDUFA2, NDUFA7, NDUFB1, NDUFB7, NDUFB11, NDUFS3, NDUFS7, TCIRG1 | |
| HP | Growth hormone signaling | up | 1.24*E-2 | 5 | FOS, IGFBP3, PIK3CG, PTPN6, STAT1 | |
| HP | Glucocorticoid receptor signaling | down | 3.12*E-2 | 15 | CDKN1A, JAK2, KRAS, MAP3K7, MNAT1, NCOA1, NR3C1, PCK2, SMAD2, SOS2, TAF5, TAT, TBP, VCAM1 | |
| 28 dpn vs. 188 dpn | AP | Glucocorticoid receptor signaling | down | 1.01*E-2 | 17 | BCL2, GTF2E2, HMGB1, HSPA2, HSPA9, HSPA14, MAP3K1, MAPK14, TBP, NCOA1, NCOR1, PIK3R1, PPP3CA, PRKACB, RAC3, STAT5B, SUMO1 |
| AP | mTOR signaling | down | 2.97*E-2 | 10 | EIF4E, EIF4G2, EIF4G3, PIK3R1, PPP2CA, PPP2CB, PPP2R1B, PRKCB, RAC3, RHOU | |
| AP | RAN Signaling | down | 1.82*E-2 | 3 | CSE1L, RAN, XPO1 | |
| AP | PPAR signaling | down | 3.69*E-2 | 7 | CITED2, MAP4K4, NCOA1, NCOR1, PDGFRA, PPARA, STAT5B | |
| HP | IGF-1 signaling | up | 2.56*E-5 | 11 | AKT3, CTGF, IGF1, IGF1R, IGFBP3, IRS1, PRKAG2, PRKCZ, PTPN11, RRAS2, SOS2 | |
| HP | mTOR signaling | up | 2.73*E-6 | 15 | AKT3, DDIT4, EIF3E, EIF4A2, EIF4B, FNBP1, IRS1, PPP2R5A, PRKAB2, PRKAG2, PRKCZ, RND3, RRAS2, STK11, VEGFA | |
| HP | AMPK signaling | up | 6.87*E-3 | 9 | AKT3, IRS1, PPM1A, PPM1D, PPP2R5A, PRKAB2, PRKAG2, SRC, STK11 | |
| HP | Fatty acid metabolism | up | 9,37*E-3 | 9 | ACAA1, ACADL, ACADSB, ACAT1, AUH, CYP2C18, CYP51A1, IVD, PTGR1 | |
| HP | Val, Leu, Ile degradation | up | 5.89*E-5 | 9 | ACAA1, ACADL, ACADSB, ACAT1, AUH, DBT, HIBCH, IVD, PCCA | |
| HP | Growth hormone signaling | up | 6.03*E-3 | 6 | IGF1, IGF1R, IGFBP3, IRS1, PRKCZ, SOCS6 | |
| HP | Purine metabolism | down | 1.90*E-4 | 17 | ABCC1, AK2, APRT, ATP13A2, BAT1, CANT1, MYO9B, NME1, NSF, PKM2, PNPT1, POLR1E, POLR2G, POLR3G, PRPS2, RRM1, RUVBL2 | |
| HP | Pyrimidine metabolism | down | 1.31*E-2 | 8 | CANT1, DKC1, NME1, PNPT1, POLR1E, POLR2G, POLR3G, RRM1 |
The comparison between dietary gestational protein levels (AP, HP) is shown in dependence of the regulatory direction (up or down).