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. 2011 Jul 18;6(7):e22148. doi: 10.1371/journal.pone.0022148

Figure 6. Proposed signaling pathways leading to SPI1 and SOCS3 gene expression.

Figure 6

A thick arrow toward hematopoietic transcription factor PU.1 encoded by SPI1 gene is a novel pathway reported in this study. Signaling from ABL1 to STAT5A, STAT5B, or STAT3 (dotted arrow) leading to SOCS3 and PU.1 expression is suggested by this study but its generalization in leukemic patients requires further validation. A negative feedback loop from JAK2 to STAT proteins and to SOCS3, which inhibits JAK2, was previously established. Enhanced expression of PU.1 may be involved in MPN development via its transcriptional control of genes regulating cellular proliferation and differentiation.