Table 1.
The top 41 probe sets from the basal mRNA expression and MPA AUC cytotoxicity phenotype association analysis with α <0.05. The gene symbols used are the official symbols approved by the HUGO Gene Nomenclature Committee, and the gene IDs correspond to those used by the NCBI Entrez Gene database. The q-values correspond to Storey and Tibshirani’s false discovery q-values [32]. The q-value of a particular association is the expected fraction of false positives in all the other associations with a more significant p-value than this particular association.
| Probe ID | Gene Symbol | Gene ID | Chromosome Location | p-value | r | Bonferroni p-value | q-value |
|---|---|---|---|---|---|---|---|
| 227620_at | SLC44A1 | 23446 | 9q31.2 | 4.02 × 10−9 | −0.348 | 2.20 × 10−4 | 8.75 × 10−5 |
| 231984_at | MTAP | 4507 | 9p21 | 5.98 × 10−9 | −0.344 | 3.26 × 10−4 | 8.75 × 10−5 |
| 223158_s_at | NEK6 | 10783 | 9q33.3-q34.11 | 7.97 × 10−9 | 0.342 | 4.35 × 10−4 | 8.75 × 10−5 |
| 213353_at | ABCA5 | 23461 | 17q24.3 | 1.04 × 10−8 | 0.339 | 5.70 × 10−4 | 8.75 × 10−5 |
| 223159_s_at | NEK6 | 10783 | 9q33.3-q34.11 | 1.47 × 10−8 | 0.336 | 8.03 × 10−4 | 8.75 × 10−5 |
| 242009_at | SLC6A4 | 6532 | 17q11.2 | 1.50 × 10−8 | 0.336 | 8.21 × 10−4 | 8.75 × 10−5 |
| 226024_at | COMMD1 | 150684 | 2p15 | 1.75 × 10−8 | 0.334 | 9.56 × 10−4 | 8.75 × 10−5 |
| 222453_at | CYBRD1 | 79901 | 2q31.1 | 4.09 × 10−8 | 0.326 | 2.24 × 10−3 | 1.53 × 10−4 |
| 219628_at | ZMAT3 | 64393 | 3q26.32 | 4.59 × 10−8 | 0.325 | 2.51 × 10−3 | 1.53 × 10−4 |
| 211932_at | HNRNPA3 | 220988 | 2q31.2 | 4.60 × 10−8 | −0.325 | 2.51 × 10−3 | 1.53 × 10−4 |
| 204137_at | GPR137B | 7107 | 1q42-q43 | 4.82 × 10−8 | 0.324 | 2.63 × 10−3 | 1.53 × 10−4 |
| 201930_at | MCM6 | 4175 | 2q21 | 4.96 × 10−8 | −0.324 | 2.71 × 10−3 | 1.53 × 10−4 |
| 224596_at | SLC44A1 | 23446 | 9q31.2 | 5.53 × 10−8 | −0.323 | 3.02 × 10−3 | 1.58 × 10−4 |
| 201689_s_at | TPD52 | 7163 | 8q21 | 5.96 × 10−8 | −0.322 | 3.25 × 10−3 | 1.59 × 10−4 |
| 208808_s_at | HMGB2 | 3148 | 4q31 | 6.56 × 10−8 | −0.321 | 3.58 × 10−3 | 1.64 × 10−4 |
| 228361_at | E2F2 | 1870 | 1p36 | 9.64 × 10−8 | −0.317 | 5.26 × 10−3 | 2.27 × 10−4 |
| 201970_s_at | NASP | 4678 | 1p34.1 | 1.15 × 10−7 | −0.315 | 6.27 × 10−3 | 2.30 × 10−4 |
| 228485_s_at | SLC44A1 | 23446 | 9q31.2 | 1.15 × 10−7 | −0.315 | 6.29 × 10−3 | 2.30 × 10−4 |
| 201266_at | TXNRD1 | 7296 | 12q23-q24.1 | 1.59 × 10−7 | −0.312 | 8.66 × 10−3 | 2.64 × 10−4 |
| 201890_at | RRM2 | 6241 | 2p25-p24 | 1.61 × 10−7 | −0.312 | 8.81 × 10−3 | 2.64 × 10−4 |
| 205692_s_at | CD38 | 952 | 4p15 | 1.69 × 10−7 | −0.311 | 9.25 × 10−3 | 2.64 × 10−4 |
| 201795_at | LBR | 3930 | 1q42.1 | 1.71 × 10−7 | −0.311 | 9.36 × 10−3 | 2.64 × 10−4 |
| 219874_at | SLC12A8 | 84561 | 3q21.2 | 1.79 × 10−7 | 0.311 | 9.79 × 10−3 | 2.65 × 10−4 |
| 235421_at | MAP3K8 | 1326 | 10p11.23 | 1.94 × 10−7 | 0.310 | 0.0106 | 2.78 × 10−4 |
| 225312_at | COMMD6 | 170622 | 13q22 | 2.02 × 10−7 | 0.309 | 0.0110 | 2.79 × 10−4 |
| 212518_at | PIP5K1C | 23396 | 19p13.3 | 2.37 × 10−7 | 0.308 | 0.0129 | 3.03 × 10−4 |
| 228486_at | SLC44A1 | 23446 | 9q31.2 | 2.50 × 10−7 | −0.307 | 0.0137 | 3.03 × 10−4 |
| 219293_s_at | OLA1 | 29789 | 2q31.1 | 2.69 × 10−7 | 0.306 | 0.0147 | 3.16 × 10−4 |
| 206879_s_at | NRG2 | 9542 | 5q23-q33 | 2.79 × 10−7 | 0.306 | 0.0152 | 3.18 × 10−4 |
| 205240_at | GPSM2 | 29899 | 1p13.3 | 3.61 × 10−7 | −0.303 | 0.0197 | 3.90 × 10−4 |
| 206668_s_at | SCAMP1 | 9522 | 5q14.1 | 3.96 × 10−7 | −0.302 | 0.0216 | 4.07 × 10−4 |
| 224984_at | NFAT5 | 10725 | 16q22.1 | 4.34 × 10−7 | 0.301 | 0.0237 | 4.33 × 10−4 |
| 219424_at | EBI3 | 10148 | 19p13.3 | 4.77 × 10−7 | 0.300 | 0.0260 | 4.65 × 10−4 |
| 222364_at | SLC44A1 | 23446 | 9q31.2 | 5.22 × 10−7 | −0.299 | 0.0285 | 4.96 × 10−4 |
| 244033_at | C14orf145 | 145508 | 14q31.1 | 5.54 × 10−7 | −0.299 | 0.0303 | 5.04 × 10−4 |
| 209460_at | ABAT | 18 | 16p13.2 | 5.75 × 10−7 | 0.298 | 0.0314 | 5.11 × 10−4 |
| 229873_at | KCTD21 | 283219 | 11q14.1 | 6.00 × 10−7 | 0.298 | 0.0327 | 5.20 × 10−4 |
| 232635_at | C14orf145 | 145508 | 14q31.1 | 7.35 × 10−7 | −0.296 | 0.0401 | 6.00 × 10−4 |
| 214369_s_at | RASGRP2 | 10235 | 11q13 | 7.73 × 10−7 | −0.295 | 0.0422 | 6.18 × 10−4 |
| 223071_at | IER3IP1 | 51124 | 18q12 | 8.06 × 10−7 | −0.295 | 0.0440 | 6.32 × 10−4 |
| 213195_at | C17orf108 | 201229 | 17q11.2 | 8.43 × 10−7 | 0.294 | 0.0460 | 6.36 × 10−4 |