Table 1.

MIC of C-2 and C-3 modified quinolones in E. coli and M. smegmatis.

Compound	C-2	C-3	C-7	Bacterial Strain (MIC μg/mL)
				E. colia	E. coli tolCb	M. smegmatisc
Ciprofloxacin	H	CO2H	Piperazinyl	0.04	0.008	0.156
13	H	H	Piperazinyl	50	1.56	6.25
Ulifloxacin	Thiazetidine	CO2H	Piperazinyl	0.062	0.016	3.13
15	Thiazetidine	H	Piperazinyl	>200	200	200
Moxifloxacin	H	CO2H	octahydropyrrolopyridinyl	0.156	0.004	0.08
11	H	H	octahydropyrrolopyridinyl	>200	100	>200
7a	S-ethyl	CO2H	Piperazinyl	200	12.5	>200
7b	S-ethyl	CO2H	octahydropyrrolopyridinyl	>50	>50	50
9a	S-ethyl	H	Piperazinyl	>50	25	>50
9b	S-ethyl	H	octahydropyrrolopyridinyl	>200	100	>200
9c	S-isopropyl	H	Piperazinyl	>50	>50	>50
9d	S-isopropyl	H	octahydropyrrolopyridinyl	>50	50	50

^aKD65

^bKD1397

^cKD1163